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KMID : 0355220120370030147
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Journal of Korean Academy Oral Medicine
2012 Volume.37 No. 3 p.147 ~ p.154
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Minimally Invasive Laser-Assisted Biopsy of the Oral Lesions for Oral Graft-Versus-Host Disease after Hematopoietic Stem-Cell Transplantation
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Kim Yun-Mi
Yun Hee-Jung
Kim Hyun-Sil
Kim Ki-Deok
Jung Bock-Young
Pang Nan-Sim
Park Won-Se
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Abstract
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Hematopoietic stem-cell transplantation (HSCT) is a treatment for immune deficiency, autoimmune diseases, and hematopoietic malignancies. The main complication of allogenic HSCT is graft-versus-host disease (GVHD). Oral mucosal biopsy is needed for a definitive diagnosis and treatment planning of GVHD, but this procedure causes bleeding and bacteremia in a poor general condition. We evaluated the efficacy of laser-assisted biopsy as a minimally invasive treatment. Three cases were described in this article. All patients’ medical records, clinical photographs, and histopathologic findings were reviewed. All patients felt comfortable and no severe complications occurred. The quality of the obtained biopsy material was adequate for a definitive diagnosis of GVHD. Laser-assisted, minimally invasive biopsy of the oral mucosa does not cause bleeding, and it reduces the chances of infection, bacteremia, and postoperative scarring compared to the usual histopathologic biopsy procedure. It would thus be advantageous to use this procedure to biopsy GVHD patients.
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KEYWORD
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Allogenic bone marrow transplantation, Biopsy, Graft vs Host Disease, Er, Cr:YSGG lasers
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